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        陈化兰研究员 一级岗位人才

        浏览次数: 日期:2010年11月12日

        陈化兰:女,博士,研究员,博士生导师,中国农业科学院兽医兽药学科“一级岗位杰出人才”,中国农业科学院哈尔滨兽医研究所农业部动物流感重点开放实验室主任,国家禽流感参考实验室主任,世界卫生组织动物流感全球监测网络中国监测实验室负责人,世界动物卫生组织(OIE)/国际粮农组织(FAO)禽流感网络(OFFLU)中国实验室负责人。 

        学习和培训经历:

        1987-1991年,就读于甘肃农业大学兽医系,获学士学位;

        1991-1994年,就读于甘肃农业大学兽医系兽医病理专业,获硕士学位;

        1994-1997年,就读于中国农业科学院研究生院传染病与预防兽医学专业,获博士学位;

        1999-2002年,美国疾病控制中心(CDC)流感分中心,博士后。 

        主要科研工作经历:

        1997-1999,中国农业科学院哈尔滨兽医研究所助理研究员;

        2002-今,中国农业科学院哈尔滨兽医研究所研究员,农业部动物流感重点开放实验室主任,国家禽流感参考实验室主任。

        1994年以来,一直从事禽流感及猪流感相关基础研究和应用研究。先后主持国家“攻关”、“863”、“973”、国家自然科学基金等科研项目10多项;主持的“H5亚型禽流感灭活疫苗研制及其应用”获得2005年国家科技进步一等奖;在国内外学术刊物发表论文近100篇;已获得4个禽流感疫苗新兽药证书,其中2个为基因工程疫苗;申请5项国家发明专利,获得3项。

        荣誉和奖励:

        1.何梁何利基金青年科技创新奖,2006

        2.中国青年五四奖章,2006

        3.国家科技进步一等奖,2005

        4.中华农业英才奖,2005

        5.中国青年女科学家奖,2005

        主要发表文章:

        1.Xijun Wang, Jingying Ge, Sen Hu, Jinhua Wang, Zhiyuan Wen, Hualan Chen, Zhigao Bu. Efficacy of DNA Immunization with F and G Protein Genes of Nipah Virus. Ann. N.Y. Acad. Sci. 2006, 1081: 243-245

        2.Jingying Ge, Zhiyuan Wen, Xijun Wang, Sen Hu, Yonggang Liu, Xiangang Kong, Hualan Chen, Zhigao Bu. Generating Vesicular Stomatitis Virus Pseudotype Bearing the Severe Acute Respiratory Syndrome Coronavirus Spike Envelope Glycoprotein for Rapid and Safe Neutralization Test or Cell-Entry Assay Ann. N.Y. Acad. Sci. 2006, 1081: 246-248

        3.Chuanling Qiao, Guobin Tian, Yongping Jiang, Yanbing Li, Jianzhong Shi, Kangzhen Yu, Hualan Chen. Vaccines Developed for H5 Highly Pathogenic Avian Influenza in China. Ann. N.Y. Acad. Sci. 2006, 1081: 182–192

        4.Jinying Ge, Guohua Deng, Zhiyuan Wen, Guobing Tian, Yong Wang, Jianzhong Shi, Xijun Wang, Yanbing Li, Sen Hu, Yongping Jiang, Chinglai Yang, Kangzhen Yu, Zhigao Bu, Hualan Chen. Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. Journal of Virology, 2007, 81, 150-158,epub., Oct. 18th , 2006

        5.Zejun Li, Yongping Jiang, Peirong Jiao, Aiqin Wang, Fengju Zhao, Guobin Tian, Xijun Wang, Kangzhen Yu, Zhigao Bu and Hualan Chen. The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses. Journal of Virology, 2006, 80:11115-11123, epub., Sept. 13th .

        6.Taronna R. Maines, Li-Mei Chen, Yumiko Matsuoka, Hualan Chen, Thomas Rowe, Juan Ortin, Ana Falco´ n, Nguyen Tran Hien, Le Quynh Mai, Endang R. Sedyaningsih, Syahrial Harun, Terrence M. Tumpey, Ruben O. Donis, Nancy J. Cox, Kanta Subbarao, and Jacqueline M. Katz. Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model. Proc. Natl. Acad. Sci. USA, 2006, 103(32): 12121-12126

        7.Hualan Chen, Yanbing Li, Zejun Li, Jianzhong Shi, Kyoko Shinya, Guohua Deng, Qiaoling Qi, Guobin Tian, Shufang Fan, Haidan Zhao, Yingxiang Sun, Yoshihiro Kawaoka. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. Journal of Virology, 2006, 80(12):5976-83.

        8.Yanbing Li, Chengjun Li, Liling Liu, Hongwei Wang, Chuanbin Wang, Guobing Tian, Robert. G. Webster, Kangzhen Yu, Hualan Chen. Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China. Virus Genes, 2006, 33:117-122

        9.Yanbing Li, Zhixiong Lin, Jianzhong Shi, Qiaoling Qi, Guohua Deng, Zejun Li, Xiurong Wang, Guobin Tian, Hualan Chen. Detection of Hong Kong 97-like H5N1 influenza viruses from eggs of Vietnamese waterfowl. Archives of Virology. 2006, 151: 1615-1624

        10.Yu H, Shu Y, Hu S, Zhang H, Gao Z, Chen H, Dong J, Xu C, Zhang Y, Xiang N, Wang M, Guo Y, Cox N, Lim W, Li D, Wang Y, Yang W. The first confirmed human case of avian influenza A (H5N1) in Mainland China. Lancet. 2006, 7: 367(9504):84.

        11.Qiao C, Yu K, Jiang Y, Li C, Tian G, Wang X, Chen H. Development of a recombinant fowlpox virus vector-based vaccine of H5N1 subtype avian influenza. Dev Biol (Basel). 2006;124:127-32.

        12.Zejun Li, Hualan Chen, Peirong Jiao, Guohua Deng, Guobin Tian, Yanbing Li, Erich Hoffmann, Robert G. Webster, Yumiko Matsuoka, Kangzhen Yu. Molecular basis associated with replication of duck H5N1 influenza viruses in a mammalian mouse model. Journal of Virology, 2005, 79: 12058–12064

        13.Guobin Tian, Suhua Zhang, Yanbing Li, Zhigao Bu, Peihong Liu, Jinping Zhou, Chengjun Li, Jianzhong Shi, Kangzhen Yu, Hualan Chen. Protective efficacy in chickens, geese and ducks of an H5N1 inactivated vaccine developed by reverse genetics. Virology, 2005, 341: 153 – 162

        14.Chengjun Li, Kangzhen Yu, Guobin Tian, Dandan Yu, Liling Liu, Bo Jing, Jihui Ping, and Hualan Chen. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China. Virology, 2005, 340 (2005) 70 – 83

        15.K. M. Sturm-Ramirez, D. J. Hulse-Post, E. A. Govorkova, J. Humberd, P. Seiler, P. Puthavathana, C. Buranathai, T. D. Nguyen, A. Chaisingh, H. T. Long, T. S. P. Naipospos, H. Chen, T. M. Ellis, Y. Guan, J. S. M. Peiris, and R. G. Webster. Are Ducks Contributing to the Endemicity of Highly Pathogenic H5N1 Influenza Virus in Asia. Journal of Virology, 2005, 79(17): 11269-11279

        16.D. J. Hulse-Post, K. M. Sturm-Ramirez, J. Humberd, P. Seiler, E. A. Govorkova, S. Krauss, C. Scholtissek, P. Puthavathana, C. Buranathai, T. D. Nguyen, H. T. Long, T. S. P. Naipospos, H. Chen, T. M. Ellis, Y. Guan, J. S. M. Peiris and R. G. Webster. Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proc. Natl. Acad. Sci. USA, 2005, 102: 10682-10687

        17.H. Chen,G. Deng,Z. Li,G. Tian,Y. Li,P. Jiao, L. Zhang, Z. Liu, R. G. Webster, K. Yu. The evolution of H5N1 influenza viruses in ducks in Southern China. Proc. Natl. Acad. Sci. USA, 2004, 101(28): 10452-10457

        18.Hualan Chen, Yumiko Matsuoka, David Swayne, Qi Chen, Nancy Cox, Brain R. Murphy and Kanta Subbarao. Generation and Characterization of an H9N2 Cold-Adapted Reassortant as a Vaccine Candidate, Avian Diseases 2003, 47, 1127-1130

        19.Yumiko Matsuoka, Hualan Chen, David Swayne, Safety Evaluation in Chickens of Candidate Human Vaccines against Potential Pandemic Strains of Influenza Avian Diseases, 2003, 47, 926-930

        20.Hualan Chen, Yumiko Matsuoka, David Swayne, Qi Chen, Nancy Cox, Brain R. Murphy and Kanta Subbarao. Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza vaccine candidate. Vaccine, 2003, 21(27-28): 4430-4436

        21.Hualan Chen, Kanta Subbarao, David Swayne, Qi Chen, Xiuhua Lu, Jacqueline Katz, Nancy Cox and Yumiko Matsuoka, Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate. Vaccine 2003, 21(17): 1974-1979

        22.Kanta Subbarao, Hualan Chen, David Swayne, Louise Mingay, Ervin Fodor, George Brownlee, Xiyan Xu, Xiuhua Lu, Jacqueline Katz, Nancy Cox and Yumiko Matsuoka Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. Virology, 2003,1.Jan 5,305(1): 192-200

        23.Hualan Chen, Kangzhen Yu, Yongping Jiang, Xiuying Tang. DNA immunization elicits high HI antibody and protects chicken from AIV challenge, International Congress Series 1219, 2001: 917-921

        联系方式:

        通讯地址:哈尔滨市南岗区马端街427号中国农业科学院哈尔滨兽医研究所
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        电话: 86-451-85935079 (办)
        传真: 86-451-82733132 
        Email: hlchen1@yahoo.com

        所属类别: 研发实力

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